منابع مشابه
Autophagy in Innate Recognition of Pathogens and Adaptive Immunity
Autophagy is a specialized cellular pathway involved in maintaining homeostasis by degrading long-lived cellular proteins and organelles. Recent studies have demonstrated that autophagy is utilized by immune systems to protect host cells from invading pathogens and regulate uncontrolled immune responses. During pathogen recognition, induction of autophagy by pattern recognition receptors leads ...
متن کاملAutophagy in the regulation of pathogen replication and adaptive immunity.
Autophagy is an evolutionarily conserved homeostatic process by which cells deliver cytoplasmic material for degradation into lysosomes. Autophagy may have evolved as a nutrient-providing homeostatic pathway induced upon starvation, but with the acquisition of cargo receptors, autophagy has become an important cellular defence mechanism as well as a generator of antigenic peptides for major his...
متن کاملAutophagy and innate immunity.
munity-related GTPase M) and NOD2 (nucleotide-binding oligomerization domain 2)] results in the development of immune-related diseases, such as Crohn’s disease, a chronic inflammatory bowel disease [2] . Autophagy represents an ancient immune defense strategy present in flies. Importantly, as flies lack an adaptive immune system, the function of autophagy in cellintrinsic innate immunity can be...
متن کاملRoles of Autophagy and Autophagy-Related Proteins in Antifungal Immunity
Autophagy was initially characterized as a process to digest cellular components, including damaged cell organelles or unused proteins. However, later studies showed that autophagy plays an important role to protect hosts from microbial infections. Accumulating evidences showed the contribution of autophagy itself and autophagy-related proteins (ATGs) in the clearance of bacteria, virus, and pa...
متن کاملAutophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity
The inspection of the mechanisms through which autophagy modulates immunogenic cell death revealed that the autophagic response of cancer cells to reactive oxygen species-dependent endoplasmic reticulum stress suppresses the exposure of calreticulin on the cell surface, the phenotypic maturation of dendritic cells (DCs) as well as their ability to release interleukin-6 and to support the prolif...
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ژورنال
عنوان ژورنال: Immunology
سال: 2010
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2010.03321.x